A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

Pain is sensed by the activation of painful nociceptors in periphery or pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from damaged tissue, afferent transmission to medulla spinalis, transmission stages high centers over dorsal horn. Pain, which was seen only a warning sign past, now accepted phenomenon itself that needs be treated search for new, stronger active substances with fewer side effects treatment demand. Hydrogen sulfide (H2S) modulator T-type Ca+2 channels, especially Cav3.2, are known play critical role processing pain. H2S can also show an anti-nociceptive effect opening K+ channels blocking nociceptors. Exciting preclinical data has demonstrated H2S-derived Non-steroidal antiinflammatory drugs (NSAIDs) analgesic agents used treat various types increases resistance gastric mucosa against injury occurred relief accelerates its repair, so it provides advantage derivatized drugs. In addition, donors have been shown induce analgesia through μ-opioid receptors. Based on studies, thought combination opioid receptor agonists may provide additive even synergistic effect. It estimated modification H2S, currently prevent increase effects, promising wise approach.